What level of the drug (low, medium, or high) should Dr. Ryder give him? What level of the drug (low, medium, or high) should Dr. Ryder give him? Explain your answer. 5c. In your own words, summarize how knowing someone’s TPMT DNA sequence could be used to determine what kind of medical care they should […]
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In the paragraphs above, circle the correct answer (high or low, heterozygous or homozygous). “Pharmacogenetics” by Jeanne Ting Chowning Page 8 Part V – SNPs and TPMT DNA techniques reveal TPMT gene is located on chromosome 6, is about 34 kilobases in length (34,000 DNA bases), and has 8 exons. An exon is a region
Describe the relationship between TPMT enzyme activity levels and TGN levels Describe the relationship between TPMT enzyme activity levels and TGN levels. Be sure to include supporting data from the graph. “Pharmacogenetics” by Jeanne Ting Chowning Page 7 Part IV – Putting It All Together From her research, Dr. Ryder hypothesized that patients such as
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Why would individuals with the lowest level of enzyme get the sickest when they take the drug? Suggest one possible reason. Investigating further, Dr. Ryder decides to look at drug levels in many patients who are all receiving the same standard doses of the thiopurine drug and compare them to enzyme levels. When she compares
Why do you think that there is more variation between patients than shown in the simplified graph? Challenge question: The actual graph (below) showed much more detail. Why do you think that there is more variation between patients than shown in the simplified graph? Figure 3. Histogram RBC TPMT frequency distribution histogram for 298 randomly
How does enzyme activity level vary among the patients examined? Answer the question: “How does enzyme activity level vary among the patients examined?” In your answer, be sure to include supporting data from the graph above. Explain how these data support your conclusion. Place Your Order Here!
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Which bar represents individuals who might be homozygous for a high enzyme activity version of the gene? Which bar (low, medium, or high) represents individuals who might be homozygous for a “low enzyme activity’” version of the gene? Which bar represents individuals who might be homozygous for a “high enzyme activity” version of the gene?
Which bar (low, medium, or high) represents individuals who might be homozygous for a low enzyme activity version of the gene? Which bar (low, medium, or high) represents individuals who might be homozygous for a “low enzyme activity’” version of the gene? Which bar represents individuals who might be homozygous for a “high enzyme activity”
Which bar represents heterozygotes? Which bar (low, medium, or high) represents individuals who might be homozygous for a “low enzyme activity’” version of the gene? Which bar represents individuals who might be homozygous for a “high enzyme activity” version of the gene? Which bar represents heterozygotes? Place Your Order Here!
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Would you expect the actual/observed number of patients to be different? Why might there be differences? 2b. Each individual inherits two copies of the gene for the enzyme, one from each parent. Dr. Ryder suspects that variation in enzyme activity level is controlled by two different versions (alleles) of that gene. Does this graph (and
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